Fig. 7. Effect of TES on regulating store operated calcium entry (SOCE) during exposure to pro-inflammatory cytokines (TNFα and IL-13) in human ASM cells. A) Representative traces of SOCE in cells exposed vehicle, TNFα, TES and TES + TNFα. B) Effect of TES on regulating SOCE during exposure to TNFα and IL-13 in human ASM cells. C) Effect of TES on the expression of STIM1 in the presence/absence of TNFα and IL-13. D) Effect of TES on the expression of Orai1 in the presence/absence of TNFα and IL-13. E) Effect of TES on the expression of TMEM66 (SARAF) in the presence/absence of TNFα and IL-13. ^##p<0.01 and ^###p<0.001 vs. vehicle and *p<0.05, **p<0.01 and ***p<0.001 vs TNFα. Data expressed as mean ± SEM. n=5 patients (non-asthmatic males).